Effective natural interferon-alpha therapy in recombinant interferon- alpha-resistant patients with hairy cell leukemia
نویسندگان
چکیده
منابع مشابه
Treatment of hairy cell leukemia with recombinant alpha 2 interferon.
Nine patients with progressive hairy cell leukemia were treated with subcutaneous injections of recombinant alpha 2 interferon (2 to 10 X 10(6) U/m2) three times weekly. Eight patients completed at least eight weeks of treatment and were evaluable; one patient with refractory thrombocytopenia died of an intracerebral hemorrhage after two doses of interferon. Seven of eight patients responded, w...
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To elucidate the mechanisms of alpha-interferon's (alpha-INF) therapeutic effect on clinical and laboratory findings in hairy cell leukemia, we sequentially monitored different immunologic parameters in three patients treated with recombinant alpha-INF. The most evident effect of this treatment on the immune system was the recovery of natural killer (NK) cell in vitro activity of peripheral blo...
متن کاملHairy-cell leukemia and alpha-interferon treatment: long-term responders.
BACKGROUND AND OBJECTIVE In the 1980s alpha-interferon (alpha-IFN) dramatically improved the management of hairy cell leukemia (HCL), producing normalization of hematologic parameters including the disappearance of circulating hairy cells in the majority of treated patients, within 6 months. The quality and durability of the response depended on the duration of alpha-IFN treatment; progression ...
متن کاملTreatment of Hairy Cell Leukemia With Recombinant Alpha Interferon: I. Quantitative Study of Bone Marrow Changes
Seventeen patients with hairy cell leukemia (HCL) were treated with low doses of recombinant alpha interferon (IFN) for over 4 months. Marked improvement was observed in peripheral blood and bone marrow in 1 5 of 17 patients. Comparison of pretreatment values and hemograms obtained after 4 months of treatment showed a marked decrease in circulating hairy cells (P < .01 ). a decrease in the numb...
متن کاملIn vivo induction of proteins during therapy of hairy cell leukemia with alpha-interferon.
The mechanism of the antineoplastic effect of interferon (IFN) is not known and may result from direct effects on the neoplastic cells themselves, activation of intermediary effector cells, or a combination of these effects. The synthesis of specific proteins is induced in hairy cells when they are exposed to alpha-IFN in vitro. In particular, the called p80, is markedly induced. We investigate...
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ژورنال
عنوان ژورنال: Blood
سال: 1991
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v78.1.38.bloodjournal78138